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We note, though, that many experiments demonstrating in vitro and in vivo effects of these drugs have been carried out (as summarized in the Introduction) and that glutathione-like activity (including recycling of ascorbic acid and the transformation of dehydroascorbic acid back into ascorbic acid) has been demonstrated for both intact GPCR and for many of the peptides tested here [48,49,50,51,52]
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